Polysac3-DB

About Glyco3d

Glyco3D features a family of databases covering the 3D features of monos, di, oligo, polysaccharides, glycosyltransferases, lectins, monoclonal antibodies and glycosaminoglycan-binding proteins. Other databases are also made available that completes the picture of glycan 3D structure decoding. that are made freely available to the scientific community. A search engine has been developed that scans the full content of all the data bases for queries related to sequential information of the carbohydrates or other related descriptors. This database ensemble offers a unique opportunity to characterize the 3D features that a given oligosaccharide can assume in different environments.

Jmol:
an open-source Java viewer for chemical structures in 3D is needed; it can It can be downloaded from SourceForge at this address: http://jmol.sourceforge.net/

A common nomenclature has been adopted that conforms to the recommendations for carbohydrates and including the constraints required by the developing field of glycobiology in terms of visualization and encoding. The set of following rules specifies the nomenclature used throughout all the data bases.

Residue Letter Name: Rib, Ara, Xyl, Lyx, All, Alt, Glc, Man, Gul, Ido, Gal, Tal, ….and abbreviated trivial name.

[O-ester and ethers]: (when present) are shown attached to the symbol with a number, e.g.
  • 6Ac for 6-O-acetyl group
  • 3S for 3-O-sulfate group
  • 6P for 6-O-phosphate group
  • 6Me for 6-O-methyl group
  • 36Anh for 3,6-anhydro
  • Pyr for pyruvate group

Absolute Configuration: D or L The D-configuration for monosaccharide and the L configuration for Fucose and Idose are implicit and does not appear in the symbol. Otherwise the L configuration is indicated in the symbol, as in the case of Arabinose or L-Galactose.

Anomeric configuration: The nature of the glycosidic configuration (α or β) is explicitly set within the symbol.
A detailed description of the monosaccharide nomenclature used in Glyco3D is presented in “The Symbolic Representation of Monosaccharides in the Age of Glycobiology” at www.glycopedia.eu Nomenclature

The syntax used to encode glycans in Glyco3D is exemplified below, along with some existing notations and graphical representations.
Nomenclature
Macromolecular builders are also made available for generating three-dimensional structures of polysaccharides, complex carbohydrates and complex solid state architectures such as glyco-gold nano particles.

Downloading Jmol. Jmol is an interactive web browser applet that is an open-source, cross-platform 3D Java visualizing tool for visualizing chemical and molecular structures. It provides 3D rendering with standard available hardware. . http://www.jmol.org/ Downloading the atomic coordinates for further independent and using a stand-alone viewer is another option

Contact us :
To contribute your structures to these data bases or for more information you can contact:
Centre de Recherches sur les Macromolécules Végétales (CERMAV-CNRS)
BP 53 X
38041 Grenoble cedex 9
France

Email : glyco3d@cermav.cnrs.fr
Phone : 33 (0) 76 03 76 36

About Us

The research leading to this set of data bases has received funding from the European Commission’s Framework Programme FP6, contract number MRTN-2004-005645, FP7/2007-2013 under grant agreement n°215536 and n°213592 and from the Agence Nationale de la Recherche under the “Genomic and Plant Biotechnology” Action throughout the “Wall-Array” project.

Scientists

Anita SARKAR

Bioligo

Serge PEREZ

[mono/di]saccharide,
bioligo, mAbs, GAG

Alain RIVET

Anne IMBERTY

Lectin

Christelle BRETON

GT

Sophie DROUILLARD

NMR

IT Team

Alexandre FINET

Séverin CONCAS

Jean-René COURTOIS

Hervé VALENTIN

Web design

Annette; HELLEBOIS

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